Eli Lilly (LLY)

Salud / Farmacéutica

GLP-1 duopoly leader: trailing-twelve-month revenue +49.6%, ex-IPR&D operating margin of 47.9%, tirzepatide patented through 2036. At ~$1,183 (EV/EBIT ~29×) 5-year base ~$1,488 (+6%/year with buybacks and dividend): Fairly valued — an exceptional business at a price of perfection; the base scenario, with revenue doubling over five years, leaves a moderate return.

Moat Compounder estimates the intrinsic value of Eli Lilly (LLY) at $1,488 per share on a five-year horizon. With the stock at $1,182.62 at 2026-10-12 close, the expected total return is 5.5% per year: fairly valued. The analysis draws on 10-K FY2025 and 10-Q Q1 2026. Analysis dated 2026-08-05.

Price
$1,182.62
at 2026-10-12 close
Intrinsic value (5y, base)
$1,488
Total annual return (5y)
5.5%
4.7% price · 0.8% div
Status (nominal)
Fairly valued
Margin of safety
+5%

The essentials

  • GLP-1 duopoly leader: Mounjaro (+91% in Q2'26, to $9.9bn) and Zepbound (+46%, to $4.9bn) make up 64.7% of first-half revenue. TTM revenue $79.7bn (+49.6%), ex-IPR&D operating margin 47.9%.
  • Tirzepatide patent through 2036 (US) — an unusually long runway — and an enormous manufacturing barrier ($50bn+ invested, 10 new sites). orforglipron (oral GLP-1) approved in Apr-2026 expands the market beyond injectables.
  • But the price: EV/EBIT ~29× on ex-IPR&D operating income, above the pharmaceutical band (14-22×). The base case (revenue doubling to ~US$158 billion, already spectacular) yields ~+6%, and even the favorable scenario returns +6%.
Source 10-K FY2025 Dec-31-2025 ·10-Q Q1 2026 Mar-31-2026 ·DEF 14A 2026 (proxy) Mar-20-2026 ·10-Q Q2 2026 Jun 30, 2026 ·8-K Q2'26 (Ex-99.1, earnings release and 2026 guidance) Aug 5, 2026
Health: Solid
Price $1,183 at 2026-10-12 closeMarket Cap $1,057.3 bnEnterprise Value $1,103.2 bnNet debt $46 bnEV/EBIT (today) 28.9x

Intrinsic value — two valuation methods

Fairly valued
Price market
$1,183
DCF value today
$1,171
-1.0% vs price
Multiples value today
$1,241
+4.9% vs price

Total return at 5 years: 5.5%/year = 4.7% appreciation + 0.8% dividend. The target price ($1,488) is ex-dividend; the $54 in dividends collected over 5 years are added separately.

The methods disagree: one places the value today above the price ($1,183) and the other below.

Pillars of the analysis

The verdict — today vs 5 years

Today — fairly valued: at $1,183 trades ~4.7% below its value discounted to today (~$1,241); the discount is positive but does not reach the margin of safety we require (≥38%).

At 5 years — En valor: the target price ($1,488) plus dividends yield between the 4% floor and the 10% average return — a reasonable return, though without the margin of a great investment.

The bridge: the return at 5 years exceeds the risk-free rate (4.5%) — but the discount does not reach the required margin of safety (≥38%). To require a 15% annual return, it would need to be bought at ~$774.

Thesis

The business

Eli Lilly is the leader of the GLP-1 duopoly and one of the best businesses in pharma: trailing-twelve-month revenue up 49.6% (+48% in the second quarter of 2026), an ex-IPR&D operating margin of 47.9% (up from 27% in 2021 — extraordinary operating leverage), and a three-layer moat (tirzepatide patent through 2036, unreplicable manufacturing scale, and its own successor pipeline with oral orforglipron already approved and retatrutide in Phase 3). The quality of the business is not in question.

The valuation

A pharmaceutical company is valued on EV/EBIT over normalized operating income (neutralizing volatile acquired-R&D charges), with the pipeline valued separately. At ~$1,183, Lilly trades at ~29× EV/EBIT, above the ceiling of the pharmaceutical band (22×).

The base scenario projects revenue doubling to ~US$158 billion over five years (decelerating from ~+17% toward ~+13%, with the MFN pricing cut offset by volume and the oral pill), an operating margin of ~47%, and multiple compression toward ~17.5× EV/EBIT (still a premium given the patent horizon). That gives ~$1,488/share in five years → an annual return of ~+6%. The upside is bounded by multiple compression: paying ~29× today leaves little margin even with operating income doubling.

The margin of safety

It trades close to intrinsic value, far from the required margin of safety. The scenarios make it explicit: even the favorable one —revenue of ~US$181 billion and an operating margin approaching ~52% by year five— returns +6% from $1,183; the market is already pricing in near-flawless execution. The verdict is Fairly valued: the margin of safety (price against value brought to today) is far from the 38% the method requires. It is an exceptional business at a price that leaves little margin.

What to watch

The risk isn't the business, it's the price and pricing policy. Overvaluation resolves either with time (revenue growing into the multiple over years) or with a correction. Watch: the depth of the MFN/IRA cut (how much further does the realized price compress?), competition for the next generation of treatments, the sustainability of tirzepatide/retatrutide's efficacy lead, and execution of the manufacturing expansion. The pipeline optionality (retatrutide, the deep Alzheimer's/oncology/cardio pipeline) is free upside, not in the base case — it's what could justify the price if it matures.

Educational / informational. Does not constitute investment advice.

Other companies of the same type